nash-profiler (BETA 1)
Murine models are a central mechanistic platform to study fatty liver disease. In order to facilitate systematic, genome-wide mRNA expression analyses, NASH-Profiler provides data of four human and five common murine models of non-alcoholic fatty liver disease.
- Human samples
- Healthy controls (n=39)
- Healthy obese (n=25)
- Non Alcoholic Fatty Liver Disease (NAFLD, n=27)
- Non Alcoholic Steato Hepatitis (NASH, n=25)
- Murine samples
- PTEN: Phosphatase and tensin homologue (PTEN) knock-out mice (n=3/3)
- HF12: High fat diet with high fructose in drinking water for 12 weeks (n=4/5)
- HF18: High fat diet with high fructose in drinking water for 18 weeks (n=5/5)
- MCD4: methionine and choline deficient diet for 4 weeks (n=5/5)
- MCD8: methionine and choline deficient diet for 8 weeks (n=5/5)
- STZ12: High fat diet with high fructose in drinking water for 12 weeks plus streptozotocin injection (50 µg) at 8 weeks (n=4/5)
- STZ 18: High fat diet with high fructose drinking water for 18 weeks plus streptozotocin injection (50 µg) at 14 weeks (n=5/5)
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Full analysis (human) |
Full analysis (murine) |
Merged analysis (human, murine) |